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A TORNADO causing heavy damage has touched down in Missouri after severe storms ripping through the US midwest killed at least 15 overnight.

The twister hit the southern part of Sedalia - a city of over 20,000 - after 12.20pm local time, damaging homes and businesses, according to the Kansas City Star.

Resident Clayton Wright told the newspaper that he emerged from his basement after the storm and saw "a lot of damage" in his neighbourhood.

"Tree limbs are down. Tops of houses are gone. There is even one house that is missing," he said.

Aerial television footage showed several homes destroyed among twisted rubble and splintered, uprooted trees. A mobile home park appeared to have suffered major damage.

About 15 people were treated for minor injuries at Bothwell Regional Health Center, but were not admitted, spokeswoman Lisa Church told NewsCore.

Sedalia is about 240km northeast of Joplin, Missouri, where the single deadliest tornado recorded by the National Weather Service killed over 120 people on Sunday.

Another round of punishing storms in the region overnight was blamed for the deaths of at least nine people in Oklahoma and two in Kansas, local media reported, while four were found dead in Arkansas, according to the state's Homeland Security and Preparedness Agency.

US President Barack Obama expressed his concern over the storms yesterday at a joint news conference in London with British Prime Minister David Cameron.

"We have been battered by storms not just over last week, but over the last months. Knowing that we have got friends in the UK [who have us in their] thoughts and prayers makes all [the] difference, thanks," Obama said.